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Medicine side effects in dogs

994,418 reports to the FDA about dogs, covering 417 medicines with enough reports to analyse. Pick a medicine to see what was reported.

Flea and tick treatment

Spinosad (Comfortis)57,095 reports Lufenuron + Milbemycin Oxime (Sentinel)26,051 reports Imidacloprid + Moxidectin (Advantage Multi)13,117 reports Nitenpyram (Capstar)10,782 reports Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum)9,966 reports Fipronil + S-methoprene (Frontline Plus)2,954 reports Flumethrin + Imidacloprid (Seresto)2,273 reports Imidacloprid1,908 reports Fipronil1,411 reports Lufenuron1,018 reports Imidacloprid + Permethrin + Pyriproxyfen740 reports Cyphenothrin + Fipronil + S-methoprene648 reports Imidacloprid + Permethrin468 reports Amitraz + Fipronil + S-methoprene460 reports Fipronil + Pyriproxyfen + S-methoprene431 reports Cyphenothrin + Fipronil287 reports Imidacloprid + Pyriproxyfen267 reports

Macrocyclic lactone (heartworm and parasite prevention)

Ivermectin + Pyrantel (Heartgard Plus)147,644 reports Milbemycin Oxime + Spinosad (Trifexis)129,736 reports Moxidectin (ProHeart 6)50,598 reports Milbemycin Oxime + Praziquantel (Interceptor Plus)31,526 reports Milbemycin Oxime (Interceptor)29,766 reports Selamectin (Revolution)29,390 reports Ivermectin (Heartgard)12,017 reports Ivermectin + Praziquantel + Pyrantel (Iverhart Max)8,523 reports Moxidectin + Pyrantel + Sarolaner (Simparica Trio)1,160 reports Ivermectin + Praziquantel204 reports Eprinomectin105 reports Moxidectin + Praziquantel75 reports

Corticosteroid

Prednisone8,940 reports Dexamethasone2,724 reports Prednisolone + Trimeprazine2,094 reports Prednisolone1,211 reports Miconazole + Polymyxin B + Prednisolone1,090 reports Dexamethasone + Neomycin + Thiabendazole645 reports Dexamethasone + Neomycin + Polymyxin B161 reports Dexamethasone + Neomycin75 reports

Antibiotic

Amoxicillin + Clavulanate (Clavamox)5,376 reports Doxycycline4,014 reports Cefovecin (Convenia)3,789 reports Enrofloxacin (Baytril)3,769 reports Metronidazole3,090 reports Amoxicillin1,349 reports Enrofloxacin + Silver Sulfadiazine210 reports Enrofloxacin + Ketoconazole + Triamcinolone95 reports

Isoxazoline flea and tick medicine

Fluralaner (Bravecto)68,765 reports Afoxolaner (NexGard)57,082 reports Sarolaner (Simparica)16,661 reports Lotilaner (Credelio)9,960 reports Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS)9,258 reports Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro)3,081 reports

Dewormer

Pyrantel + Sarolaner (Simparica Trio)53,360 reports Febantel + Praziquantel + Pyrantel (Drontal Plus)6,706 reports Fenbendazole5,882 reports Pyrantel4,786 reports Praziquantel + Pyrantel3,685 reports Praziquantel1,108 reports

Non-steroidal anti-inflammatory drug (NSAID)

Carprofen (Rimadyl)47,320 reports Deracoxib (Deramaxx)11,010 reports Grapiprant (Galliprant)8,780 reports Meloxicam (Metacam)8,083 reports Firocoxib (Previcox)8,006 reports Robenacoxib (Onsior)115 reports

Vaccine

Rabies Vaccine9,911 reports Bordetella Vaccine9,399 reports Leptospirosis Vaccine8,017 reports Lyme Vaccine7,004 reports Distemper-parvo Vaccine6,476 reports Bordetella Vaccine + Distemper-parvo Vaccine82 reports

Hormone or endocrine medicine

Trilostane (Vetoryl)11,924 reports Insulin7,358 reports Phenylpropanolamine (Proin)4,138 reports Levothyroxine3,012 reports Velagliflozin (Senvelgo)72 reports

Behaviour or anxiety medicine

Gabapentin9,020 reports Selegiline (Anipryl)4,119 reports Fluoxetine2,583 reports Trazodone2,530 reports Clomipramine (Clomicalm)1,512 reports

Anti-itch medicine

Oclacitinib (Apoquel)28,968 reports Cyclosporine (Atopica)15,302 reports Ilunocitinib (Zenrelia)2,198 reports

Stomach and nausea medicine

Maropitant (Cerenia)11,884 reports Capromorelin (Entyce)1,515 reports Mirtazapine (Mirataz)289 reports

Monoclonal antibody injection

Bedinvetmab (Librela)19,619 reports Lokivetmab (Cytopoint)6,510 reports

Sedative or anaesthetic

Dexmedetomidine (Dexdomitor)5,470 reports Buprenorphine1,585 reports

Heart medicine

Pimobendan (Vetmedin)5,701 reports

Other medicines

Melarsomine (Immiticide)22,672 reports Polysulfated Glycosaminoglycan5,465 reports Diphenhydramine4,724 reports Butorphanol4,441 reports Cefpodoxime4,055 reports Tramadol3,768 reports Florfenicol + Mometasone + Terbinafine3,542 reports Desoxycorticosterone Pivalate3,337 reports Propofol3,072 reports Dirlotapide2,805 reports Isoflurane2,767 reports Cephalexin2,680 reports Atipamezole2,656 reports Famotidine2,643 reports Chondroitin + Glucosamine2,619 reports Clotrimazole + Gentamicin + Mometasone2,614 reports Betamethasone + Florfenicol + Terbinafine2,447 reports Genta Momet Clotrim2,294 reports Ketoconazole2,256 reports Medetomidine2,127 reports Tigilanol Tiglate2,026 reports Estriol2,023 reports Betamethasone + Clotrimazole + Gentamicin1,964 reports Ketamine1,875 reports Etodolac1,868 reports Glucosamine1,808 reports Acepromazine1,756 reports Enalapril1,649 reports S-methoprene1,638 reports Phenobarbital1,544 reports Furosemide1,518 reports Fish Oil1,510 reports Tiletamine + Zolazepam1,454 reports Marbofloxacin1,224 reports Midazolam1,205 reports Tepoxalin1,089 reports Toceranib1,080 reports Clindamycin1,075 reports Hydromorphone1,061 reports Hydroxyzine1,034 reports Sucralfate986 reports Ampicillin977 reports Omeprazole953 reports Sulfadimethoxine920 reports Triamcinolone889 reports Ormetoprim + Sulfadimethoxine877 reports Pentobarbital + Phenytoin848 reports Sevoflurane837 reports Atropine749 reports Amitraz748 reports Ursodiol731 reports Diazepam683 reports Levetiracetam679 reports Methylprednisolone674 reports Ondansetron665 reports Cetirizine663 reports Rabacfosadine655 reports Tylosin641 reports Benazepril636 reports Fentanyl628 reports Methocarbamol623 reports Metoclopramide591 reports Medetomidine + Vatinoxan575 reports Diethylcarbamazine + Oxibendazole508 reports Amantadine508 reports Alfaxalone495 reports Permethrin + Pyriproxyfen487 reports Neomycin + Triamcinolone464 reports Gentamicin + Hydrocortisone Aceponate + Miconazole460 reports Neomycin440 reports Verdinexor433 reports Genta Betamet Clotrim430 reports Epsiprantel423 reports Mometasone + Orbifloxacin + Posaconazole423 reports Dasuquin422 reports Cefazolin421 reports Imrab Tf -417 reports Fuzapladib Sodium411 reports Potassium Bromide402 reports Alprazolam402 reports Miconazole399 reports Adequan399 reports S-adenosylmethionine392 reports Denamarin387 reports Vitamin B12378 reports Heartgard377 reports Atinvicitinib377 reports Gentamicin + Miconazole368 reports Amlodipine363 reports Omega Fatty Acids360 reports Dapp357 reports Orbifloxacin330 reports Epinephrine313 reports Fluconazole312 reports Zonisamide308 reports Morphine305 reports Thyroxine305 reports Betamethasone + Gentamicin301 reports Pantoprazole299 reports Pyriproxyfen297 reports Tacrolimus297 reports Ropinirole Hydrochloride286 reports Vitamins284 reports Hydrocodone269 reports Unspecified262 reports Recombinant Interleukin-257 reports Melatonin256 reports S-adenosylmethionine Silybin254 reports Penicillin253 reports Neomycin + Nystatin + Thiostrepton + Triamcinolone252 reports Xylazine251 reports Lidocaine245 reports Benadryl241 reports Diethylcarbamazine240 reports Proin239 reports Imepitoin239 reports Methadone238 reports Delmopinol231 reports Mercaptobenzothiazole229 reports Gentamicin228 reports Bupivacaine228 reports Interceptor223 reports Ketoprofen215 reports Hydrogen Peroxide212 reports Telmisartan206 reports Allergy203 reports Cosequin200 reports Bravecto200 reports Neomycin + Polymyxin B195 reports Spironolactone195 reports Dextrose189 reports Hexetidine187 reports Anesthesia187 reports Interceptor Plus187 reports Chlorhexidine + Ophytrium186 reports Interleukin- Monoclonal Antibody185 reports Ciprofloxacin180 reports Keppra179 reports Oxygen178 reports Aspirin176 reports Theophylline176 reports Salicylic Acid174 reports Nexgard171 reports Chlorhexidine Gluconate + Climbazole + Phytosphingosine Salicyloyl170 reports Omega167 reports Device Surgical Instruments160 reports Heartgard Plus158 reports Masitinib Mesylate156 reports Acetylsalicylic Acid156 reports Neomycin + Nystatin Usp + Thiostrepton Usp + Triamcinolone156 reports Chlorhexidine155 reports Incurin154 reports Tresaderm Dermatological153 reports Vetmedin153 reports Mupirocin150 reports Milk Thistle144 reports Loratidine143 reports Cannabidiol143 reports Proviable142 reports Entyce141 reports Docp139 reports Albendazole137 reports Terbinafine137 reports Steroid135 reports Chlorpheniramine135 reports Vitamin K133 reports Amitriptyline130 reports Apomorphine130 reports Lactated Ringers128 reports Primidone124 reports Glycopyrrolate121 reports Tobramycin118 reports Phytosphingosine112 reports Ofloxacin111 reports Meclizine109 reports Imidocarb Dipropionate108 reports Antihistamines108 reports Ceftiofur107 reports Device Suture107 reports Azathioprine107 reports Activated Charcoal107 reports Cough107 reports Vitamin E104 reports Doramectin103 reports Tris Edta101 reports Potassium Chloride101 reports Liquid Dish Soap101 reports Sodium Chloride100 reports Dexdomitor100 reports Prebiotics Microorganisms100 reports Clopidogrel99 reports Phytosphingosine Hydrochloride98 reports Vetprofen98 reports Claro98 reports Imrab -97 reports Budesonide97 reports Previcox97 reports Chlorhexidine Digluconate96 reports Loratadine95 reports Cortisone94 reports Deramaxx94 reports Sedative92 reports Hyaluronic Acid91 reports Bupivacaine Lipsome90 reports Lactulose89 reports Same89 reports Sentinel89 reports Lasix88 reports Trifexis88 reports Meclofenamic Acid87 reports Ciprofloxacin Hcl87 reports Chlorpheniramine Maleate87 reports Cleansing87 reports Apoquel87 reports Piroxicam86 reports Artificial Tears86 reports Laser Therapy85 reports Unspecified Anesthesia85 reports Ophytrium85 reports Metacam84 reports Fatty Acids83 reports Pergolide82 reports Potassium Citrate82 reports Cbd Oil82 reports Vetoryl82 reports Fatty Acid81 reports Permethrin81 reports Flunixin Meglumine79 reports Dhpp79 reports Pilocarpine78 reports Vitamin B Complex78 reports Panacur78 reports Saline78 reports Desmopressin77 reports Penicillin G Procaine76 reports Chlorphenamine76 reports Hydrocortisone75 reports Benazapril75 reports Plasma75 reports Codeine75 reports Ursodeoxycholic Acid75 reports Polymyxin B74 reports Proheart74 reports Chlorhexidine Gluconate + Ketoconazole + Phytosphingosine Salicyloyl74 reports Difloxacin Hydrochloride73 reports Bbpi Lb Lv73 reports Pentoxifylline72 reports Diclofenac72 reports Ponazuril71 reports Baytril71 reports Acupuncture71 reports Mycophenolate70 reports Chondroitin69 reports Premise Spray69 reports Sildenafil68 reports Hetastarch68 reports Pregabalin68 reports Unspecified Steroid67 reports Aminopentamide66 reports Recombitek Lepto -66 reports Dichlorophene Toluene65 reports Device Catheter65 reports Cleanser65 reports Deltamethrin65 reports Otic Cleanser65 reports Soloxine64 reports Aluminum Hydroxide63 reports Flush63 reports Fludrocortisone62 reports Azithromycin62 reports Vitamin B62 reports Misoprostol62 reports Minocycline62 reports Immiticide62 reports Dish Soap62 reports Credelio62 reports Phenobarbitol61 reports Blood Transfusion61 reports S-adenosylmethionine And Silybin61 reports Acetylcysteine61 reports Pepcid61 reports Phytosphingosine Salicyloyl61 reports Chloramphenicol60 reports Sulfamethoxazole Trimethoprim60 reports Frontline Plus60 reports Chlorhexidine Gluconate60 reports Anesthesia Gas60 reports Sotalol60 reports Fortiflora60 reports Acetaminophen58 reports Detomidine57 reports Cerenia57 reports Carporfen56 reports Betamethasone + Terbinafine56 reports Thyro-55 reports Advantage Multi55 reports Dolasetron54 reports Chlorhexidine Gluconate + Phytosphingosine Salicyloyl54 reports Divested Suanovil54 reports Bupivacaine Liposome54 reports Vincristine53 reports Fenthion52 reports Silver Sulfadiazine52 reports Rimadyl52 reports Antibacterial Anti-inflammatory Antifungal52 reports Bismuth Subsalicylate52 reports Eye Lubricant52 reports Microchip52 reports Lysozyme Lactoferrin52 reports Asit52 reports Sam-e52 reports Niacinamide51 reports Dhlpp51 reports Unspecified Cleanser51 reports Drontal51 reports Claro Otic51 reports Monoclonal Antibody51 reports Ranitidine50 reports Novox50 reports Atenolol50 reports Chinese Herbs50 reports Zyrtec50 reports Welactin50 reports Same And Silybin50 reports Neomycin + Nystatin + Thiostrepton50 reports Benazepril + Spironolactone50 reports Nexgard Plus50 reports

Most reported reactions in dogs

Vomiting 274,715 reports
Didn't prevent heartworm 127,289 reports
Didn't work as expected 126,696 reports
Lethargy 112,907 reports
Diarrhea 83,908 reports
Didn't stop worms 83,737 reports
Loss of appetite 83,055 reports
Didn't stop fleas 61,168 reports
Death 51,415 reports
Liver problems 45,348 reports
Seizures 43,537 reports
Itching 43,237 reports
Tremors 34,043 reports
Swelling 27,642 reports
Breathing problems 26,396 reports
Wobbliness (ataxia) 25,766 reports
Behaviour change 24,963 reports
Kidney problems 23,413 reports
Didn't stop ticks 23,064 reports
Allergic reaction 23,008 reports
Digestive tract disorder 20,084 reports
Blood problems 17,418 reports
Weight loss 16,794 reports
Restlessness or agitation 15,895 reports
Accidental exposure 15,359 reports
Drooling 14,288 reports
Excessive thirst 13,805 reports
Weakness 13,527 reports
Fever 13,425 reports
Skin rash or irritation 12,617 reports

All reactions › · By breed ›