Pyrantel + Sarolaner (Simparica Trio) side effects in dogs
53,360 reports sent to the FDA between 2020 and 2026 involve Pyrantel + Sarolaner in dogs. The most reported problems were vomiting, seizures, diarrhea. 56% were marked serious, and where it was recorded, signs eased after stopping the medicine in 27% of cases.
About this medicine
Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.
Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (39,037 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 3,798 reports
- Golden Retriever 2,465 reports
- German Shepherd Dog 1,794 reports
- Australian Shepherd Dog 1,173 reports
- Bull - American Pit Terrier 940 reports
- Yorkshire Terrier 910 reports
- Shih Tzu 864 reports
- Chihuahua 809 reports
- French Bulldog 657 reports
- Beagle 648 reports