Vomiting after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 10,822 reports of vomiting in dogs after Pyrantel + Sarolaner. That is 20% of all reports for this medicine, compared with 28% across reports for all dog medicines.

10,822Reports

24%Marked serious

52%Recovered

1.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

8,143 77%

1–2 days

1,440 14%

3–7 days

333 3.2%

1–4 weeks

284 2.7%

Over a month

354 3.4%

How the animals did

Recovered

5,655 52%

Recovered with lasting effects

2 0.0%

Still unwell when reported

2,264 21%

Died

96 0.9%

Euthanised

101 0.9%

Not known

2,704 25%

Problems reported at the same time

2,218 20%

1,535 14%

1,218 11%

530 4.9%

411 3.8%

249 2.3%

247 2.3%

227 2.1%

Age of the animals

Under 1 year

2,668

1–3 years

3,467

4–7 years

1,903

8–11 years

1,074

12+ years

488

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause vomiting in dogs?: 10,822 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Febantel + Praziquantel + Pyrantel (Drontal Plus) 3,844 reports · 57% of its reports
Vomiting after Fenbendazole 2,054 reports · 35% of its reports
Vomiting after Pyrantel 1,528 reports · 32% of its reports
Vomiting after Praziquantel + Pyrantel 1,813 reports · 49% of its reports
Vomiting after Praziquantel 255 reports · 23% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with vomiting