Lethargy after Pyrantel + Sarolaner (Simparica Trio) in dogs

3,702 reports to the FDA describe lethargy in dogs given Pyrantel + Sarolaner. That is 6.9% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported less often than average with this medicine.

3,702Reports

47%Marked serious

34%Recovered

4.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

1,925 54%

1–2 days

939 26%

3–7 days

289 8.1%

1–4 weeks

206 5.8%

Over a month

206 5.8%

How the animals did

Recovered

1,243 34%

Recovered with lasting effects

1 0.0%

Still unwell when reported

1,434 39%

Died

86 2.3%

Euthanised

90 2.4%

Not known

848 23%

Problems reported at the same time

1,535 41%

1,354 37%

896 24%

561 15%

357 9.6%

318 8.6%

231 6.2%

230 6.2%

Age of the animals

Under 1 year

783

1–3 years

1,113

4–7 years

810

8–11 years

573

12+ years

257

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause lethargy in dogs?: 3,702 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Febantel + Praziquantel + Pyrantel (Drontal Plus) 651 reports · 9.7% of its reports
Lethargy after Fenbendazole 1,078 reports · 18% of its reports
Lethargy after Pyrantel 928 reports · 19% of its reports
Lethargy after Praziquantel + Pyrantel 956 reports · 26% of its reports
Lethargy after Praziquantel 148 reports · 13% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with lethargy