Behaviour change after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 1,082 reports of behaviour change in dogs after Pyrantel + Sarolaner. That is 2.0% of all reports for this medicine, compared with 2.5% across reports for all dog medicines.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause behaviour change in dogs?

1,082 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

• Behaviour change after Febantel + Praziquantel + Pyrantel (Drontal Plus) 285 reports · 4.2% of its reports
• Behaviour change after Fenbendazole 213 reports · 3.6% of its reports
• Behaviour change after Pyrantel 103 reports · 2.2% of its reports
• Behaviour change after Praziquantel + Pyrantel 147 reports · 4.0% of its reports
• Behaviour change after Praziquantel 31 reports · 2.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with behaviour change