Breathing problems after Pyrantel + Sarolaner (Simparica Trio) in dogs

762 reports to the FDA describe breathing problems in dogs given Pyrantel + Sarolaner. That is 1.4% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

762Reports
77%Marked serious
25%Recovered
16%Died or euthanised
1 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
345 48%
1–2 days
153 21%
3–7 days
59 8.3%
1–4 weeks
75 11%
Over a month
81 11%

How the animals did

Recovered
190 25%
Still unwell when reported
303 40%
Died
70 9.2%
Euthanised
51 6.7%
Not known
148 19%

Problems reported at the same time

230 30%
200 26%
192 25%
160 21%
120 16%
97 13%

Age of the animals

Under 1 year
83
1–3 years
194
4–7 years
191
8–11 years
182
12+ years
87

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause breathing problems in dogs?
762 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with breathing problems