Seizures after Pyrantel + Sarolaner (Simparica Trio) in dogs

4,687 reports to the FDA describe seizures in dogs given Pyrantel + Sarolaner. That is 8.8% of all reports for this medicine, compared with 4.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause seizures in dogs?

4,687 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

• Seizures after Febantel + Praziquantel + Pyrantel (Drontal Plus) 108 reports · 1.6% of its reports
• Seizures after Fenbendazole 185 reports · 3.1% of its reports
• Seizures after Pyrantel 229 reports · 4.8% of its reports
• Seizures after Praziquantel + Pyrantel 96 reports · 2.6% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with seizures