Disorientation after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 493 reports of disorientation in dogs after Pyrantel + Sarolaner. That is 0.9% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

493Reports

67%Marked serious

36%Recovered

8.9%Died or euthanised

1 daysTypical onset

How soon it started

Same day

210 46%

1–2 days

109 24%

3–7 days

65 14%

1–4 weeks

49 11%

Over a month

26 5.7%

How the animals did

Recovered

176 36%

Still unwell when reported

174 35%

Died

17 3.4%

Euthanised

27 5.5%

Not known

99 20%

Problems reported at the same time

195 40%

138 28%

135 27%

107 22%

94 19%

82 17%

75 15%

47 9.5%

Age of the animals

Under 1 year

1–3 years

147

4–7 years

108

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause disorientation in dogs?: 493 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Febantel + Praziquantel + Pyrantel (Drontal Plus) 34 reports · 0.5% of its reports
Disorientation after Fenbendazole 46 reports · 0.8% of its reports
Disorientation after Pyrantel 33 reports · 0.7% of its reports
Disorientation after Praziquantel + Pyrantel 33 reports · 0.9% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with disorientation