Wobbliness (ataxia) after Pyrantel + Sarolaner (Simparica Trio) in dogs

1,115 reports to the FDA describe wobbliness (ataxia) in dogs given Pyrantel + Sarolaner. That is 2.1% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

1,115Reports

64%Marked serious

29%Recovered

7.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

426 40%

1–2 days

277 26%

3–7 days

131 12%

1–4 weeks

128 12%

Over a month

97 9.2%

How the animals did

Recovered

320 29%

Recovered with lasting effects

3 0.3%

Still unwell when reported

541 49%

Died

28 2.5%

Euthanised

50 4.5%

Not known

173 16%

Problems reported at the same time

377 34%

318 29%

281 25%

247 22%

184 17%

108 9.7%

94 8.4%

84 7.5%

Age of the animals

Under 1 year

273

1–3 years

260

4–7 years

210

8–11 years

194

12+ years

159

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause wobbliness (ataxia) in dogs?: 1,115 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Febantel + Praziquantel + Pyrantel (Drontal Plus) 95 reports · 1.4% of its reports
Wobbliness (ataxia) after Fenbendazole 161 reports · 2.7% of its reports
Wobbliness (ataxia) after Pyrantel 163 reports · 3.4% of its reports
Wobbliness (ataxia) after Praziquantel + Pyrantel 112 reports · 3.0% of its reports
Wobbliness (ataxia) after Praziquantel 35 reports · 3.2% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with wobbliness (ataxia)