Wobbliness (ataxia) after Praziquantel + Pyrantel in dogs

The FDA has received 112 reports of wobbliness (ataxia) in dogs after Praziquantel + Pyrantel. That is 3.0% of all reports for this medicine, compared with 2.6% across reports for all dog medicines.

112Reports
62%Marked serious
29%Recovered
12%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
58 67%
1–2 days
13 15%
3–7 days
8 9.2%
1–4 weeks
4 4.6%
Over a month
4 4.6%

How the animals did

Recovered
31 28%
Recovered with lasting effects
1 0.9%
Still unwell when reported
10 8.9%
Died
9 8.0%
Euthanised
4 3.6%
Not known
57 51%

Problems reported at the same time

Age of the animals

Under 1 year
45
1–3 years
18
4–7 years
20
8–11 years
14
12+ years
12

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause wobbliness (ataxia) in dogs?
112 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with wobbliness (ataxia)