Wobbliness (ataxia) after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

95 reports to the FDA describe wobbliness (ataxia) in dogs given Febantel + Praziquantel + Pyrantel. That is 1.4% of all reports for this medicine, compared with 2.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

95Reports

53%Marked serious

29%Recovered

14%Died or euthanised

Same dayTypical onset

How soon it started

Same day

39 57%

1–2 days

18 26%

3–7 days

4 5.8%

1–4 weeks

5 7.2%

Over a month

3 4.3%

How the animals did

Recovered

27 28%

Recovered with lasting effects

1 1.1%

Still unwell when reported

9 9.5%

Died

9 9.5%

Euthanised

4 4.2%

Not known

45 47%

Problems reported at the same time

39 41%

32 34%

18 19%

15 16%

14 15%

14 15%

13 14%

13 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause wobbliness (ataxia) in dogs?: 95 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Pyrantel + Sarolaner (Simparica Trio) 1,115 reports · 2.1% of its reports
Wobbliness (ataxia) after Fenbendazole 161 reports · 2.7% of its reports
Wobbliness (ataxia) after Pyrantel 163 reports · 3.4% of its reports
Wobbliness (ataxia) after Praziquantel + Pyrantel 112 reports · 3.0% of its reports
Wobbliness (ataxia) after Praziquantel 35 reports · 3.2% of its reports

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with wobbliness (ataxia)