Febantel + Praziquantel + Pyrantel (Drontal Plus) side effects in dogs

6,706 reports sent to the FDA between 1996 and 2026 involve Febantel + Praziquantel + Pyrantel in dogs. The most reported problems were vomiting, diarrhea, lethargy. 38% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.

6,706Reports
38%Marked serious
66%Only medicine involved
47%Recovered
3.3%Died or euthanised
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About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

3,844 57%
815 12%
651 9.7%
263 3.9%
247 3.7%
212 3.2%
157 2.3%
149 2.2%
145 2.2%
108 1.6%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't stop fleas
12 0.2%
Didn't stop ticks
4 0.1%

How soon problems started

Same day
3,241 61%
1–2 days
698 13%
3–7 days
272 5.1%
1–4 weeks
535 10%
Over a month
602 11%

Time from the first dose to the first sign, where both dates were reported (5,348 reports).

How the animals did

Recovered
3,147 47%
Recovered with lasting effects
14 0.2%
Still unwell when reported
425 6.3%
Died
176 2.6%
Euthanised
44 0.7%
Not known
2,900 43%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other dewormers for dogs