Vocalising after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 212 reports of vocalising in dogs after Febantel + Praziquantel + Pyrantel. That is 3.2% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

212Reports
33%Marked serious
37%Recovered
5.7%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
115 68%
1–2 days
23 14%
3–7 days
12 7.1%
1–4 weeks
11 6.5%
Over a month
8 4.7%

How the animals did

Recovered
76 36%
Recovered with lasting effects
2 0.9%
Still unwell when reported
19 9.0%
Died
9 4.2%
Euthanised
3 1.4%
Not known
103 49%

Problems reported at the same time

Age of the animals

Under 1 year
140
1–3 years
32
4–7 years
15
8–11 years
8
12+ years
12

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause vocalising in dogs?
212 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with vocalising