Vocalising after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 408 reports of vocalising in dogs after Pyrantel + Sarolaner. That is 0.8% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

408Reports
61%Marked serious
25%Recovered
9.3%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
174 45%
1–2 days
99 26%
3–7 days
31 8.1%
1–4 weeks
50 13%
Over a month
31 8.1%

How the animals did

Recovered
100 25%
Still unwell when reported
179 44%
Died
18 4.4%
Euthanised
20 4.9%
Not known
91 22%

Problems reported at the same time

Age of the animals

Under 1 year
120
1–3 years
106
4–7 years
76
8–11 years
54
12+ years
40

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause vocalising in dogs?
408 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with vocalising