Vocalising after Praziquantel + Pyrantel in dogs

The FDA has received 133 reports of vocalising in dogs after Praziquantel + Pyrantel. That is 3.6% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

133Reports
49%Marked serious
27%Recovered
9.0%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
73 62%
1–2 days
26 22%
3–7 days
9 7.7%
1–4 weeks
3 2.6%
Over a month
6 5.1%

How the animals did

Recovered
35 26%
Recovered with lasting effects
1 0.8%
Still unwell when reported
6 4.5%
Died
10 7.5%
Euthanised
2 1.5%
Not known
79 59%

Problems reported at the same time

Age of the animals

Under 1 year
63
1–3 years
26
4–7 years
22
8–11 years
12
12+ years
10

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause vocalising in dogs?
133 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with vocalising