Tremors after Praziquantel + Pyrantel in dogs

The FDA has received 212 reports of tremors in dogs after Praziquantel + Pyrantel. That is 5.8% of all reports for this medicine, compared with 3.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

212Reports

51%Marked serious

35%Recovered

5.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

118 69%

1–2 days

44 26%

3–7 days

5 2.9%

1–4 weeks

2 1.2%

Over a month

3 1.7%

How the animals did

Recovered

74 35%

Still unwell when reported

5 2.4%

Died

9 4.2%

Euthanised

2 0.9%

Not known

122 58%

Problems reported at the same time

82 39%

66 31%

38 18%

29 14%

23 11%

22 10%

19 9.0%

17 8.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause tremors in dogs?: 212 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Pyrantel + Sarolaner (Simparica Trio) 2,595 reports · 4.9% of its reports
Tremors after Febantel + Praziquantel + Pyrantel (Drontal Plus) 149 reports · 2.2% of its reports
Tremors after Fenbendazole 229 reports · 3.9% of its reports
Tremors after Pyrantel 198 reports · 4.1% of its reports
Tremors after Praziquantel 22 reports · 2.0% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with tremors