Behaviour change after Praziquantel + Pyrantel in dogs

The FDA has received 147 reports of behaviour change in dogs after Praziquantel + Pyrantel. That is 4.0% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

147Reports
44%Marked serious
34%Recovered
8.8%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
79 60%
1–2 days
35 27%
3–7 days
7 5.3%
1–4 weeks
8 6.1%
Over a month
3 2.3%

How the animals did

Recovered
49 33%
Recovered with lasting effects
1 0.7%
Still unwell when reported
1 0.7%
Died
9 6.1%
Euthanised
4 2.7%
Not known
83 56%

Problems reported at the same time

Age of the animals

Under 1 year
48
1–3 years
41
4–7 years
21
8–11 years
18
12+ years
11

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause behaviour change in dogs?
147 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with behaviour change