Drooling after Praziquantel + Pyrantel in dogs

105 reports to the FDA describe drooling in dogs given Praziquantel + Pyrantel. That is 2.8% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

105Reports

54%Marked serious

23%Recovered

13%Died or euthanised

Same dayTypical onset

How soon it started

Same day

51 60%

1–2 days

20 24%

3–7 days

6 7.1%

1–4 weeks

6 7.1%

Over a month

2 2.4%

How the animals did

Recovered

23 22%

Recovered with lasting effects

1 1.0%

Still unwell when reported

6 5.7%

Died

12 11%

Euthanised

2 1.9%

Not known

61 58%

Problems reported at the same time

46 44%

41 39%

27 26%

22 21%

15 14%

13 12%

13 12%

13 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause drooling in dogs?: 105 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Pyrantel + Sarolaner (Simparica Trio) 475 reports · 0.9% of its reports
Drooling after Febantel + Praziquantel + Pyrantel (Drontal Plus) 91 reports · 1.4% of its reports
Drooling after Fenbendazole 120 reports · 2.0% of its reports
Drooling after Pyrantel 116 reports · 2.4% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with drooling