Drooling after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 475 reports of drooling in dogs after Pyrantel + Sarolaner. That is 0.9% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

475Reports

64%Marked serious

28%Recovered

7.2%Died or euthanised

1 daysTypical onset

How soon it started

Same day

204 45%

1–2 days

111 25%

3–7 days

49 11%

1–4 weeks

60 13%

Over a month

29 6.4%

How the animals did

Recovered

133 28%

Still unwell when reported

214 45%

Died

11 2.3%

Euthanised

23 4.8%

Not known

94 20%

Problems reported at the same time

148 31%

142 30%

139 29%

104 22%

91 19%

79 17%

74 16%

54 11%

Age of the animals

Under 1 year

118

1–3 years

148

4–7 years

104

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause drooling in dogs?: 475 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Febantel + Praziquantel + Pyrantel (Drontal Plus) 91 reports · 1.4% of its reports
Drooling after Fenbendazole 120 reports · 2.0% of its reports
Drooling after Pyrantel 116 reports · 2.4% of its reports
Drooling after Praziquantel + Pyrantel 105 reports · 2.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with drooling