Diarrhea after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 4,331 reports of diarrhea in dogs after Pyrantel + Sarolaner. That is 8.1% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

4,331Reports

44%Marked serious

35%Recovered

2.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

2,328 56%

1–2 days

1,198 29%

3–7 days

261 6.2%

1–4 weeks

181 4.3%

Over a month

221 5.3%

How the animals did

Recovered

1,502 35%

Recovered with lasting effects

2 0.0%

Still unwell when reported

1,562 36%

Died

42 1.0%

Euthanised

45 1.0%

Not known

1,178 27%

Problems reported at the same time

2,218 51%

896 21%

781 18%

274 6.3%

162 3.7%

150 3.5%

138 3.2%

108 2.5%

Age of the animals

Under 1 year

1,034

1–3 years

1,346

4–7 years

814

8–11 years

543

12+ years

297

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause diarrhea in dogs?: 4,331 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

Diarrhea after Febantel + Praziquantel + Pyrantel (Drontal Plus) 815 reports · 12% of its reports
Diarrhea after Fenbendazole 1,091 reports · 19% of its reports
Diarrhea after Pyrantel 785 reports · 16% of its reports
Diarrhea after Praziquantel + Pyrantel 740 reports · 20% of its reports
Diarrhea after Praziquantel 139 reports · 13% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with diarrhea