Tremors after Pyrantel + Sarolaner (Simparica Trio) in dogs

2,595 reports to the FDA describe tremors in dogs given Pyrantel + Sarolaner. That is 4.9% of all reports for this medicine, compared with 3.4% across reports for all dog medicines.

2,595Reports

51%Marked serious

32%Recovered

3.6%Died or euthanised

1 daysTypical onset

How soon it started

Same day

1,230 50%

1–2 days

584 24%

3–7 days

243 9.8%

1–4 weeks

230 9.3%

Over a month

192 7.7%

How the animals did

Recovered

829 32%

Recovered with lasting effects

2 0.1%

Still unwell when reported

1,089 42%

Died

34 1.3%

Euthanised

59 2.3%

Not known

582 22%

Problems reported at the same time

583 22%

561 22%

530 20%

435 17%

377 15%

274 11%

214 8.2%

192 7.4%

Age of the animals

Under 1 year

501

1–3 years

831

4–7 years

533

8–11 years

387

12+ years

252

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause tremors in dogs?: 2,595 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Febantel + Praziquantel + Pyrantel (Drontal Plus) 149 reports · 2.2% of its reports
Tremors after Fenbendazole 229 reports · 3.9% of its reports
Tremors after Pyrantel 198 reports · 4.1% of its reports
Tremors after Praziquantel + Pyrantel 212 reports · 5.8% of its reports
Tremors after Praziquantel 22 reports · 2.0% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with tremors