Diarrhea after Praziquantel + Pyrantel in dogs

740 reports to the FDA describe diarrhea in dogs given Praziquantel + Pyrantel. That is 20% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

740Reports
38%Marked serious
24%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
266 45%
1–2 days
230 39%
3–7 days
61 10%
1–4 weeks
16 2.7%
Over a month
18 3.0%

How the animals did

Recovered
172 23%
Recovered with lasting effects
4 0.5%
Still unwell when reported
23 3.1%
Died
75 10%
Euthanised
8 1.1%
Not known
458 62%

Problems reported at the same time

Age of the animals

Under 1 year
385
1–3 years
149
4–7 years
81
8–11 years
58
12+ years
35

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause diarrhea in dogs?
740 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with diarrhea