Lethargy after Praziquantel + Pyrantel in dogs

The FDA has received 956 reports of lethargy in dogs after Praziquantel + Pyrantel. That is 26% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

956Reports
37%Marked serious
29%Recovered
10%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
425 57%
1–2 days
244 33%
3–7 days
47 6.3%
1–4 weeks
19 2.6%
Over a month
10 1.3%

How the animals did

Recovered
272 28%
Recovered with lasting effects
5 0.5%
Still unwell when reported
23 2.4%
Died
83 8.7%
Euthanised
13 1.4%
Not known
560 59%

Problems reported at the same time

Age of the animals

Under 1 year
450
1–3 years
216
4–7 years
121
8–11 years
86
12+ years
44

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause lethargy in dogs?
956 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with lethargy