Death after Praziquantel + Pyrantel in dogs

244 reports to the FDA describe death in dogs given Praziquantel + Pyrantel. That is 6.6% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

244Reports

85%Marked serious

0.0%Recovered

99%Died or euthanised

1 daysTypical onset

How soon it started

Same day

88 46%

1–2 days

72 38%

3–7 days

23 12%

1–4 weeks

7 3.6%

Over a month

2 1.0%

How the animals did

Still unwell when reported

1 0.4%

Died

204 84%

Euthanised

38 16%

Not known

1 0.4%

Problems reported at the same time

109 45%

92 38%

89 36%

79 32%

25 10%

23 9.4%

17 7.0%

15 6.1%

Age of the animals

Under 1 year

124

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause death in dogs?: 244 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Pyrantel + Sarolaner (Simparica Trio) 896 reports · 1.7% of its reports
Death after Febantel + Praziquantel + Pyrantel (Drontal Plus) 214 reports · 3.2% of its reports
Death after Fenbendazole 512 reports · 8.7% of its reports
Death after Pyrantel 693 reports · 14% of its reports
Death after Praziquantel 50 reports · 4.5% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with death