Weakness after Praziquantel + Pyrantel in dogs

The FDA has received 79 reports of weakness in dogs after Praziquantel + Pyrantel. That is 2.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

79Reports

71%Marked serious

16%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

32 51%

1–2 days

19 30%

3–7 days

5 7.9%

1–4 weeks

6 9.5%

Over a month

1 1.6%

How the animals did

Recovered

13 16%

Still unwell when reported

3 3.8%

Died

14 18%

Euthanised

1 1.3%

Not known

48 61%

Problems reported at the same time

37 47%

32 41%

26 33%

20 25%

15 19%

13 16%

9 11%

7 8.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause weakness in dogs?: 79 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weakness with similar medicines

Weakness after Pyrantel + Sarolaner (Simparica Trio) 352 reports · 0.7% of its reports
Weakness after Febantel + Praziquantel + Pyrantel (Drontal Plus) 50 reports · 0.7% of its reports
Weakness after Fenbendazole 146 reports · 2.5% of its reports
Weakness after Pyrantel 118 reports · 2.5% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with weakness