Death after Pyrantel + Sarolaner (Simparica Trio) in dogs

896 reports to the FDA describe death in dogs given Pyrantel + Sarolaner. That is 1.7% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause death in dogs?

896 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 2 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

• Death after Febantel + Praziquantel + Pyrantel (Drontal Plus) 214 reports · 3.2% of its reports
• Death after Fenbendazole 512 reports · 8.7% of its reports
• Death after Pyrantel 693 reports · 14% of its reports
• Death after Praziquantel + Pyrantel 244 reports · 6.6% of its reports
• Death after Praziquantel 50 reports · 4.5% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with death