Liver problems after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 695 reports of liver problems in dogs after Pyrantel + Sarolaner. That is 1.3% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

695Reports

80%Marked serious

9.5%Recovered

13%Died or euthanised

3 daysTypical onset

How soon it started

Same day

174 29%

1–2 days

111 18%

3–7 days

67 11%

1–4 weeks

105 17%

Over a month

152 25%

How the animals did

Recovered

65 9.4%

Recovered with lasting effects

1 0.1%

Still unwell when reported

472 68%

Died

37 5.3%

Euthanised

55 7.9%

Not known

65 9.4%

Problems reported at the same time

249 36%

198 28%

191 27%

153 22%

138 20%

107 15%

92 13%

82 12%

Age of the animals

Under 1 year

1–3 years

186

4–7 years

170

8–11 years

154

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause liver problems in dogs?: 695 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Febantel + Praziquantel + Pyrantel (Drontal Plus) 70 reports · 1.0% of its reports
Liver problems after Fenbendazole 140 reports · 2.4% of its reports
Liver problems after Pyrantel 126 reports · 2.6% of its reports
Liver problems after Praziquantel + Pyrantel 31 reports · 0.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with liver problems