Liver problems after Praziquantel + Pyrantel in dogs

31 reports to the FDA describe liver problems in dogs given Praziquantel + Pyrantel. That is 0.8% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

31Reports
90%Marked serious
19%Recovered
13%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
8 31%
1–2 days
6 23%
3–7 days
4 15%
1–4 weeks
6 23%
Over a month
2 7.7%

How the animals did

Recovered
5 16%
Recovered with lasting effects
1 3.2%
Still unwell when reported
10 32%
Died
3 9.7%
Euthanised
1 3.2%
Not known
11 35%

Problems reported at the same time

Age of the animals

Under 1 year
12
1–3 years
6
4–7 years
5
8–11 years
5
12+ years
3

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause liver problems in dogs?
31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with liver problems