Liver problems after Pyrantel in dogs

The FDA has received 126 reports of liver problems in dogs after Pyrantel. That is 2.6% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

126Reports

60%Marked serious

7.9%Recovered

34%Died or euthanised

5 daysTypical onset

How soon it started

Same day

22 25%

1–2 days

18 20%

3–7 days

15 17%

1–4 weeks

16 18%

Over a month

18 20%

How the animals did

Recovered

9 7.1%

Recovered with lasting effects

1 0.8%

Still unwell when reported

44 35%

Died

21 17%

Euthanised

22 17%

Not known

29 23%

Problems reported at the same time

67 53%

58 46%

46 37%

44 35%

44 35%

31 25%

31 25%

22 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Pyrantel cause liver problems in dogs?: 126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Pyrantel + Sarolaner (Simparica Trio) 695 reports · 1.3% of its reports
Liver problems after Febantel + Praziquantel + Pyrantel (Drontal Plus) 70 reports · 1.0% of its reports
Liver problems after Fenbendazole 140 reports · 2.4% of its reports
Liver problems after Praziquantel + Pyrantel 31 reports · 0.8% of its reports

All reported side effects of Pyrantel in dogs · Medicines most reported with liver problems