Seizures after Praziquantel + Pyrantel in dogs

The FDA has received 96 reports of seizures in dogs after Praziquantel + Pyrantel. That is 2.6% of all reports for this medicine, compared with 4.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

96Reports

91%Marked serious

24%Recovered

25%Died or euthanised

1 daysTypical onset

How soon it started

Same day

42 49%

1–2 days

21 24%

3–7 days

9 10%

1–4 weeks

10 12%

Over a month

4 4.7%

How the animals did

Recovered

22 23%

Recovered with lasting effects

1 1.0%

Still unwell when reported

8 8.3%

Died

17 18%

Euthanised

7 7.3%

Not known

41 43%

Problems reported at the same time

25 26%

22 23%

15 16%

14 15%

12 13%

11 11%

11 11%

9 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause seizures in dogs?: 96 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Seizures with similar medicines

Seizures after Pyrantel + Sarolaner (Simparica Trio) 4,687 reports · 8.8% of its reports
Seizures after Febantel + Praziquantel + Pyrantel (Drontal Plus) 108 reports · 1.6% of its reports
Seizures after Fenbendazole 185 reports · 3.1% of its reports
Seizures after Pyrantel 229 reports · 4.8% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with seizures