Behaviour change after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 285 reports of behaviour change in dogs after Febantel + Praziquantel + Pyrantel. That is 4.2% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

285Reports

36%Marked serious

36%Recovered

6.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

140 58%

1–2 days

47 20%

3–7 days

18 7.5%

1–4 weeks

14 5.8%

Over a month

21 8.8%

How the animals did

Recovered

102 36%

Recovered with lasting effects

1 0.4%

Still unwell when reported

34 12%

Died

14 4.9%

Euthanised

3 1.1%

Not known

131 46%

Problems reported at the same time

Vomiting

89 31%

Restlessness or agitation

86 30%

65 23%

60 21%

60 21%

42 15%

27 9.5%

24 8.4%

Age of the animals

Under 1 year

116

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause behaviour change in dogs?: 285 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

Behaviour change after Pyrantel + Sarolaner (Simparica Trio) 1,082 reports · 2.0% of its reports
Behaviour change after Fenbendazole 213 reports · 3.6% of its reports
Behaviour change after Pyrantel 103 reports · 2.2% of its reports
Behaviour change after Praziquantel + Pyrantel 147 reports · 4.0% of its reports
Behaviour change after Praziquantel 31 reports · 2.8% of its reports

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with behaviour change