Restlessness or agitation after Praziquantel + Pyrantel in dogs

76 reports to the FDA describe restlessness or agitation in dogs given Praziquantel + Pyrantel. That is 2.1% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

76Reports

33%Marked serious

32%Recovered

7.9%Died or euthanised

Same dayTypical onset

How soon it started

Same day

42 68%

1–2 days

10 16%

3–7 days

3 4.8%

1–4 weeks

2 3.2%

Over a month

5 8.1%

How the animals did

Recovered

24 32%

Still unwell when reported

4 5.3%

Died

6 7.9%

Not known

42 55%

Problems reported at the same time

18 24%

16 21%

11 14%

10 13%

10 13%

9 12%

9 12%

6 7.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Praziquantel + Pyrantel cause restlessness or agitation in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Pyrantel + Sarolaner (Simparica Trio) 456 reports · 0.9% of its reports
Restlessness or agitation after Febantel + Praziquantel + Pyrantel (Drontal Plus) 443 reports · 6.6% of its reports
Restlessness or agitation after Fenbendazole 253 reports · 4.3% of its reports
Restlessness or agitation after Pyrantel 60 reports · 1.3% of its reports

All reported side effects of Praziquantel + Pyrantel in dogs · Medicines most reported with restlessness or agitation