Didn't work as expected after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

The FDA has received 376 reports of didn't work as expected in dogs after Febantel + Praziquantel + Pyrantel. That is 5.6% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported less often than average with this medicine.

376Reports

51%Marked serious

18%Recovered

1.9%Died or euthanised

22 daysTypical onset

How soon it started

Same day

12 5.2%

1–2 days

14 6.1%

3–7 days

16 7.0%

1–4 weeks

99 43%

Over a month

88 38%

How the animals did

Recovered

66 18%

Recovered with lasting effects

2 0.5%

Still unwell when reported

29 7.7%

Died

4 1.1%

Euthanised

3 0.8%

Not known

272 72%

Problems reported at the same time

91 24%

72 19%

43 11%

27 7.2%

22 5.9%

21 5.6%

Drug dose administration interval too short

15 4.0%

Underdose

15 4.0%

Age of the animals

Under 1 year

141

1–3 years

114

4–7 years

8–11 years

12+ years

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause didn't work as expected in dogs?: 376 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 22 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Pyrantel + Sarolaner (Simparica Trio) 10,725 reports · 20% of its reports
Didn't work as expected after Fenbendazole 562 reports · 9.6% of its reports
Didn't work as expected after Pyrantel 426 reports · 8.9% of its reports
Didn't work as expected after Praziquantel + Pyrantel 118 reports · 3.2% of its reports
Didn't work as expected after Praziquantel 34 reports · 3.1% of its reports

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with didn't work as expected