Drug dose administration interval too short after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

35 reports to the FDA describe drug dose administration interval too short in dogs given Febantel + Praziquantel + Pyrantel. That is 0.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

35Reports

54%Marked serious

31%Recovered

0.0%Died or euthanised

15 daysTypical onset

How soon it started

Same day

4 25%

1–2 days

2 13%

3–7 days

2 13%

1–4 weeks

2 13%

Over a month

6 38%

How the animals did

Recovered

11 31%

Still unwell when reported

2 5.7%

Not known

22 63%

Problems reported at the same time

Didn't work as expected

15 43%

11 31%

8 23%

8 23%

5 14%

4 11%

3 8.6%

2 5.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause drug dose administration interval too short in dogs?: 35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

Drug dose administration interval too short after Pyrantel + Sarolaner (Simparica Trio) 34 reports · 0.1% of its reports
Drug dose administration interval too short after Fenbendazole 35 reports · 0.6% of its reports
Drug dose administration interval too short after Pyrantel 37 reports · 0.8% of its reports

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with drug dose administration interval too short