Drug dose administration interval too short after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 34 reports of drug dose administration interval too short in dogs after Pyrantel + Sarolaner. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause drug dose administration interval too short in dogs?

34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 11 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drug dose administration interval too short with similar medicines

• Drug dose administration interval too short after Febantel + Praziquantel + Pyrantel (Drontal Plus) 35 reports · 0.5% of its reports
• Drug dose administration interval too short after Fenbendazole 35 reports · 0.6% of its reports
• Drug dose administration interval too short after Pyrantel 37 reports · 0.8% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with drug dose administration interval too short