Didn't stop worms after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 10,714 reports of didn't stop worms in dogs after Pyrantel + Sarolaner. That is 20% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

10,714Reports

87%Marked serious

2.6%Recovered

0.1%Died or euthanised

105 daysTypical onset

How soon it started

Same day

345 5.0%

1–2 days

62 0.9%

3–7 days

119 1.7%

1–4 weeks

972 14%

Over a month

5,346 78%

How the animals did

Recovered

280 2.6%

Still unwell when reported

9,601 90%

Died

4 0.0%

Euthanised

3 0.0%

Not known

826 7.7%

Problems reported at the same time

Intentional misuse

448 4.2%

Medication error

321 3.0%

Didn't work as expected

292 2.7%

50 0.5%

47 0.4%

43 0.4%

41 0.4%

39 0.4%

Age of the animals

Under 1 year

2,436

1–3 years

4,009

4–7 years

2,219

8–11 years

1,179

12+ years

410

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause didn't stop worms in dogs?: 10,714 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 105 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop worms with similar medicines

Didn't stop worms after Febantel + Praziquantel + Pyrantel (Drontal Plus) 1,252 reports · 19% of its reports
Didn't stop worms after Fenbendazole 1,224 reports · 21% of its reports
Didn't stop worms after Pyrantel 808 reports · 17% of its reports
Didn't stop worms after Praziquantel + Pyrantel 327 reports · 8.9% of its reports
Didn't stop worms after Praziquantel 403 reports · 36% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with didn't stop worms