Medication error after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 1,862 reports of medication error in dogs after Pyrantel + Sarolaner. That is 3.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,862Reports
59%Marked serious
3.7%Recovered
0.8%Died or euthanised
136 daysTypical onset
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How soon it started

Same day
135 16%
1–2 days
31 3.7%
3–7 days
12 1.4%
1–4 weeks
84 10%
Over a month
571 69%

How the animals did

Recovered
68 3.7%
Recovered with lasting effects
1 0.1%
Still unwell when reported
1,642 88%
Died
9 0.5%
Euthanised
5 0.3%
Not known
137 7.4%

Problems reported at the same time

Age of the animals

Under 1 year
168
1–3 years
811
4–7 years
529
8–11 years
220
12+ years
73

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause medication error in dogs?
1,862 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 136 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Medication error with similar medicines

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with medication error