Didn't prevent heartworm after Pyrantel + Sarolaner (Simparica Trio) in dogs

5,803 reports to the FDA describe didn't prevent heartworm in dogs given Pyrantel + Sarolaner. That is 11% of all reports for this medicine, compared with 13% across reports for all dog medicines.

5,803Reports

93%Marked serious

1.3%Recovered

0.2%Died or euthanised

300 daysTypical onset

How soon it started

Same day

65 2.2%

1–2 days

1 0.0%

3–7 days

13 0.4%

1–4 weeks

26 0.9%

Over a month

2,849 96%

How the animals did

Recovered

74 1.3%

Still unwell when reported

5,189 89%

Died

6 0.1%

Euthanised

8 0.1%

Not known

526 9.1%

Problems reported at the same time

Medication error

144 2.5%

Didn't work as expected

98 1.7%

73 1.3%

41 0.7%

40 0.7%

35 0.6%

21 0.4%

18 0.3%

Age of the animals

Under 1 year

1–3 years

3,968

4–7 years

1,153

8–11 years

350

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause didn't prevent heartworm in dogs?: 5,803 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 300 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't prevent heartworm with similar medicines

Didn't prevent heartworm after Febantel + Praziquantel + Pyrantel (Drontal Plus) 42 reports · 0.6% of its reports
Didn't prevent heartworm after Fenbendazole 65 reports · 1.1% of its reports
Didn't prevent heartworm after Pyrantel 79 reports · 1.7% of its reports
Didn't prevent heartworm after Praziquantel + Pyrantel 26 reports · 0.7% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with didn't prevent heartworm