Didn't work as expected after Pyrantel + Sarolaner (Simparica Trio) in dogs

The FDA has received 10,725 reports of didn't work as expected in dogs after Pyrantel + Sarolaner. That is 20% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

10,725Reports

47%Marked serious

2.0%Recovered

0.6%Died or euthanised

228 daysTypical onset

How soon it started

Same day

379 8.4%

1–2 days

36 0.8%

3–7 days

34 0.8%

1–4 weeks

206 4.5%

Over a month

3,873 86%

How the animals did

Recovered

212 2.0%

Still unwell when reported

9,650 90%

Died

28 0.3%

Euthanised

36 0.3%

Not known

799 7.4%

Problems reported at the same time

2,257 21%

1,342 13%

1,278 12%

292 2.7%

Didn't prevent heartworm

98 0.9%

Vomiting

79 0.7%

Drug dose omission

74 0.7%

Death

64 0.6%

Age of the animals

Under 1 year

803

1–3 years

4,810

4–7 years

2,879

8–11 years

1,406

12+ years

425

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause didn't work as expected in dogs?: 10,725 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 228 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Febantel + Praziquantel + Pyrantel (Drontal Plus) 376 reports · 5.6% of its reports
Didn't work as expected after Fenbendazole 562 reports · 9.6% of its reports
Didn't work as expected after Pyrantel 426 reports · 8.9% of its reports
Didn't work as expected after Praziquantel + Pyrantel 118 reports · 3.2% of its reports
Didn't work as expected after Praziquantel 34 reports · 3.1% of its reports

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with didn't work as expected