Not himself/herself after Pyrantel + Sarolaner (Simparica Trio) in dogs

572 reports to the FDA describe not himself/herself in dogs given Pyrantel + Sarolaner. That is 1.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

572Reports

50%Marked serious

30%Recovered

7.2%Died or euthanised

1 daysTypical onset

How soon it started

Same day

273 49%

1–2 days

144 26%

3–7 days

55 9.9%

1–4 weeks

54 9.8%

Over a month

27 4.9%

How the animals did

Recovered

172 30%

Still unwell when reported

203 35%

Died

18 3.1%

Euthanised

23 4.0%

Not known

156 27%

Problems reported at the same time

230 40%

181 32%

167 29%

124 22%

92 16%

91 16%

63 11%

50 8.7%

Age of the animals

Under 1 year

1–3 years

181

4–7 years

127

8–11 years

115

12+ years

About this medicine

Pyrantel treats roundworms and hookworms. Sarolaner kills fleas, ticks and some mites; monthly.

Products with this combination include Simparica Trio (which also contains moxidectin). The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Pyrantel + Sarolaner cause not himself/herself in dogs?: 572 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Pyrantel + Sarolaner in dogs · Medicines most reported with not himself/herself