S-adenosylmethionine Silybin side effects in dogs

254 reports sent to the FDA between 2008 and 2026 involve S-adenosylmethionine Silybin in dogs. The most reported problems were liver problems, vomiting, loss of appetite. 48% were marked serious.

254Reports
48%Marked serious
0.4%Only medicine involved
18%Recovered
11%Died or euthanised
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About this medicine

Type: medicine.

Most reported side effects

51 20%
42 17%
33 13%
Weakness
16 6.3%
Weight loss
16 6.3%
Excessive thirst
16 6.3%
Excessive urination
16 6.3%
Abnormal radiograph finding
15 5.9%
Blood problems
14 5.5%
Elevated gamma-glutamyl transferase (ggt)
14 5.5%
Loose stool
14 5.5%
Abnormal ultrasound finding
13 5.1%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't stop worms
3 1.2%
Didn't prevent heartworm
3 1.2%
Didn't stop fleas
2 0.8%

How soon problems started

Same day
21 13%
1–2 days
5 3.1%
3–7 days
5 3.1%
1–4 weeks
25 16%
Over a month
104 65%

Time from the first dose to the first sign, where both dates were reported (160 reports).

How the animals did

Recovered
41 16%
Recovered with lasting effects
4 1.6%
Still unwell when reported
95 37%
Died
8 3.1%
Euthanised
20 7.9%
Not known
86 34%

Breeds named most often

Popular breeds appear more often because there are more of them.

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