Kidney problems after S-adenosylmethionine Silybin in dogs

The FDA has received 29 reports of kidney problems in dogs after S-adenosylmethionine Silybin. That is 11% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

29Reports
69%Marked serious
10%Recovered
34%Died or euthanised
59 daysTypical onset
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How soon it started

Same day
6 32%
1–2 days
0 0.0%
3–7 days
0 0.0%
1–4 weeks
1 5.3%
Over a month
12 63%

How the animals did

Recovered
2 6.9%
Recovered with lasting effects
1 3.4%
Still unwell when reported
8 28%
Died
1 3.4%
Euthanised
9 31%
Not known
8 28%

Problems reported at the same time

11 38%
10 34%
10 34%
10 34%
Elevated gamma-glutamyl transferase (ggt)
7 24%
Elevated cholesterol (total)
7 24%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
5
8–11 years
4
12+ years
19

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine Silybin cause kidney problems in dogs?
29 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 59 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

All reported side effects of S-adenosylmethionine Silybin in dogs · Medicines most reported with kidney problems