Kidney problems after Polysulfated Glycosaminoglycan in dogs

319 reports to the FDA describe kidney problems in dogs given Polysulfated Glycosaminoglycan. That is 5.8% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

319Reports

62%Marked serious

11%Recovered

27%Died or euthanised

31 daysTypical onset

How soon it started

Same day

29 18%

1–2 days

6 3.8%

3–7 days

16 10%

1–4 weeks

28 18%

Over a month

80 50%

How the animals did

Recovered

24 7.5%

Recovered with lasting effects

10 3.1%

Still unwell when reported

85 27%

Died

34 11%

Euthanised

53 17%

Not known

113 35%

Problems reported at the same time

129 40%

114 36%

105 33%

104 33%

89 28%

63 20%

59 18%

57 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

102

12+ years

184

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause kidney problems in dogs?: 319 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Melarsomine (Immiticide) 434 reports · 1.9% of its reports
Kidney problems after Diphenhydramine 221 reports · 4.7% of its reports
Kidney problems after Butorphanol 203 reports · 4.6% of its reports
Kidney problems after Cefpodoxime 248 reports · 6.1% of its reports
Kidney problems after Tramadol 441 reports · 12% of its reports
Kidney problems after Florfenicol + Mometasone + Terbinafine 52 reports · 1.5% of its reports
Kidney problems after Desoxycorticosterone Pivalate 253 reports · 7.6% of its reports
Kidney problems after Propofol 143 reports · 4.7% of its reports
Kidney problems after Dirlotapide 78 reports · 2.8% of its reports
Kidney problems after Isoflurane 187 reports · 6.8% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with kidney problems