Liver problems after Polysulfated Glycosaminoglycan in dogs

The FDA has received 548 reports of liver problems in dogs after Polysulfated Glycosaminoglycan. That is 10% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

548Reports

56%Marked serious

6.9%Recovered

19%Died or euthanised

31 daysTypical onset

How soon it started

Same day

59 19%

1–2 days

12 3.8%

3–7 days

29 9.1%

1–4 weeks

55 17%

Over a month

162 51%

How the animals did

Recovered

30 5.5%

Recovered with lasting effects

8 1.5%

Still unwell when reported

177 32%

Died

41 7.5%

Euthanised

61 11%

Not known

231 42%

Problems reported at the same time

179 33%

148 27%

142 26%

114 21%

105 19%

99 18%

76 14%

62 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

223

12+ years

232

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause liver problems in dogs?: 548 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Melarsomine (Immiticide) 1,315 reports · 5.8% of its reports
Liver problems after Diphenhydramine 500 reports · 11% of its reports
Liver problems after Butorphanol 371 reports · 8.4% of its reports
Liver problems after Cefpodoxime 475 reports · 12% of its reports
Liver problems after Tramadol 684 reports · 18% of its reports
Liver problems after Florfenicol + Mometasone + Terbinafine 133 reports · 3.8% of its reports
Liver problems after Desoxycorticosterone Pivalate 276 reports · 8.3% of its reports
Liver problems after Propofol 201 reports · 6.5% of its reports
Liver problems after Dirlotapide 284 reports · 10% of its reports
Liver problems after Isoflurane 237 reports · 8.6% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with liver problems