Lethargy after Polysulfated Glycosaminoglycan in dogs

The FDA has received 1,037 reports of lethargy in dogs after Polysulfated Glycosaminoglycan. That is 19% of all reports for this medicine, compared with 11% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,037Reports
40%Marked serious
31%Recovered
14%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
221 35%
1–2 days
74 12%
3–7 days
46 7.3%
1–4 weeks
96 15%
Over a month
189 30%

How the animals did

Recovered
310 30%
Recovered with lasting effects
8 0.8%
Still unwell when reported
164 16%
Died
61 5.9%
Euthanised
88 8.5%
Not known
406 39%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
57
4–7 years
217
8–11 years
391
12+ years
334

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause lethargy in dogs?
1,037 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with lethargy