Liver problems after Tramadol in dogs

The FDA has received 684 reports of liver problems in dogs after Tramadol. That is 18% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

684Reports
59%Marked serious
12%Recovered
27%Died or euthanised
16 daysTypical onset
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How soon it started

Same day
38 7.2%
1–2 days
53 10%
3–7 days
88 17%
1–4 weeks
162 31%
Over a month
185 35%

How the animals did

Recovered
76 11%
Recovered with lasting effects
6 0.9%
Still unwell when reported
324 47%
Died
52 7.6%
Euthanised
135 20%
Not known
91 13%

Problems reported at the same time

Age of the animals

Under 1 year
9
1–3 years
51
4–7 years
168
8–11 years
282
12+ years
168

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause liver problems in dogs?
684 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 16 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with liver problems