Liver problems after Dirlotapide in dogs

The FDA has received 284 reports of liver problems in dogs after Dirlotapide. That is 10% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

284Reports
0.7%Marked serious
1.1%Recovered
16%Died or euthanised
33 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
0 0.0%
1–2 days
2 11%
3–7 days
2 11%
1–4 weeks
4 22%
Over a month
10 56%

How the animals did

Recovered
3 1.1%
Still unwell when reported
16 5.6%
Died
45 16%
Euthanised
1 0.4%
Not known
219 77%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
16
4–7 years
108
8–11 years
132
12+ years
19

About this medicine

Type: medicine.

Questions owners ask

Can Dirlotapide cause liver problems in dogs?
284 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 33 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Dirlotapide in dogs · Medicines most reported with liver problems