Hyperphosphataemia after Polysulfated Glycosaminoglycan in dogs

The FDA has received 68 reports of hyperphosphataemia in dogs after Polysulfated Glycosaminoglycan. That is 1.2% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

68Reports

69%Marked serious

12%Recovered

35%Died or euthanised

19 daysTypical onset

How soon it started

Same day

6 18%

1–2 days

0 0.0%

3–7 days

6 18%

1–4 weeks

6 18%

Over a month

16 47%

How the animals did

Recovered

6 8.8%

Recovered with lasting effects

2 2.9%

Still unwell when reported

14 21%

Died

9 13%

Euthanised

15 22%

Not known

22 32%

Problems reported at the same time

59 87%

43 63%

37 54%

37 54%

34 50%

25 37%

18 26%

17 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause hyperphosphataemia in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

Hyperphosphataemia after Melarsomine (Immiticide) 139 reports · 0.6% of its reports
Hyperphosphataemia after Diphenhydramine 77 reports · 1.6% of its reports
Hyperphosphataemia after Butorphanol 59 reports · 1.3% of its reports
Hyperphosphataemia after Cefpodoxime 65 reports · 1.6% of its reports
Hyperphosphataemia after Tramadol 127 reports · 3.4% of its reports
Hyperphosphataemia after Desoxycorticosterone Pivalate 71 reports · 2.1% of its reports
Hyperphosphataemia after Propofol 50 reports · 1.6% of its reports
Hyperphosphataemia after Dirlotapide 20 reports · 0.7% of its reports
Hyperphosphataemia after Isoflurane 64 reports · 2.3% of its reports
Hyperphosphataemia after Cephalexin 34 reports · 1.3% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with hyperphosphataemia