Hyperphosphataemia after Diphenhydramine in dogs

77 reports to the FDA describe hyperphosphataemia in dogs given Diphenhydramine. That is 1.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause hyperphosphataemia in dogs?

77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 1 day of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

• Hyperphosphataemia after Melarsomine (Immiticide) 139 reports · 0.6% of its reports
• Hyperphosphataemia after Polysulfated Glycosaminoglycan 68 reports · 1.2% of its reports
• Hyperphosphataemia after Butorphanol 59 reports · 1.3% of its reports
• Hyperphosphataemia after Cefpodoxime 65 reports · 1.6% of its reports
• Hyperphosphataemia after Tramadol 127 reports · 3.4% of its reports
• Hyperphosphataemia after Desoxycorticosterone Pivalate 71 reports · 2.1% of its reports
• Hyperphosphataemia after Propofol 50 reports · 1.6% of its reports
• Hyperphosphataemia after Dirlotapide 20 reports · 0.7% of its reports
• Hyperphosphataemia after Isoflurane 64 reports · 2.3% of its reports
• Hyperphosphataemia after Cephalexin 34 reports · 1.3% of its reports

All reported side effects of Diphenhydramine in dogs · Medicines most reported with hyperphosphataemia