Diphenhydramine side effects in dogs
4,724 reports sent to the FDA between 1999 and 2026 involve Diphenhydramine in dogs. The most reported problems were vomiting, lethargy, allergic reaction. 48% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.
4,724Reports
48%Marked serious
0.2%Only medicine involved
33%Recovered
9.8%Died or euthanised
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About this medicine
Type: medicine.
Most reported side effects
Share = percentage of this medicine's reports that mention the problem. One report can list several problems.
Reports that it didn't work
Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.
How soon problems started
Time from the first dose to the first sign, where both dates were reported (3,833 reports).
How the animals did
Breeds named most often
Popular breeds appear more often because there are more of them.
- Labrador Retriever 318 reports
- Chihuahua 174 reports
- Boxer (german Boxer) 161 reports
- Yorkshire Terrier 161 reports
- Bull - American Pit Terrier 160 reports
- French Bulldog 148 reports
- Shih Tzu 130 reports
- Pug 129 reports
- Dachshund 104 reports
- Golden Retriever 101 reports
Other medicines for dogs
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